Hydrogen as a treatment candidate for non-alcoholic steatohepatitis

Coumarin: an alternative candidate for the treatment of non-alcoholic steatohepatitis?

Non-alcoholic fatty liver disease (NAFLD) often manifests as the liver component of obesity, diabetes and the metabolic syndrome, and ranges from fat accumulation to steatohepatitis, and sometimes to fibrosis/cirrhosis. The high prevalence (5–20 % in the general population) of this disorder accounts for an increased incidence of end-stage liver disease and hepatocellular carcinoma in many parts...

Silymarin in treatment of non-alcoholic steatohepatitis: A randomized clinical trial

Abstract Background: No pharmacologic agents have been approved for the treatment of non-alcoholic steatohepatitis (NASH) that is common in our region. The present study was designed to evaluate the efficacy of silymarin, a known herbal drug, in the treatment of NASH. Methods: This clinical-trial study was conducted on 64 patients with NASH who were randomly divided as case group (33) and con...

Non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis in children.

Non-alcoholic steatohepatitis (NASH) is an important liver disease in children; it can cause cirrhosis in children. The disease mechanism involves hepatic insulin resistance with hyperinsulinemia and changes in certain adipocytokines and inflammatory mediators. The differential diagnosis of childhood NASH includes metabolic disorders, drug hepatotoxicity, and alcoholic hepatitis in adolescent p...

[Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis].

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome. Since the prevalence of obesity and consequently of the metabolic syndrome is steadily increasing, the different types of NAFLD are nowadays the most common cause of liver injury in North America. The development of NASH and fatty liver cirrhosis occurs af...